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The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity
ISBN: 978-0-471-49959-6
November 2001
312 pages
It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies.