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Genetic Analysis of Complex Disease, 3rd Edition

ISBN: 978-1-118-12391-1

January 2022

Wiley-Blackwell

336 pages

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Description
Genetic Analysis of Complex Diseases

An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings

In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies.

This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues.

Genetic Analysis of Complex Diseases also provides:

  • A thorough introduction to study design for the identification of genes in complex traits
  • Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease
  • Practical discussions of modern bioinformatics tools for analysis of genetic data
  • Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management
  • New expanded chapter on complex genetic interactions

This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.

About the Author
Dr. William Scott, PhD, is a professor at the University of Miami Leonard M. Miller School of Medicine, where he currently teaches a course on Genetic Analysis of Complex Human Diseases. With over 15 years of research and teaching experience in the field of human genetics and epidemiology, Dr. Scott has authored over 100 articles in journals such as JAMA and the American Journal of Human Genetics, and contributed numerous chapters and monographs to books and publications, including Wiley's Current Protocols.

Dr. Marylyn Ritchie, PhD, is an associate professor in the Department of Molecular Physiology and Biophysics at Vanderbilt University, where she is also the Director for the Progam in Computational Genomics at Vanderbilt's  Center for Human Genetics Research. In addition to her research and teaching activities Dr. Ritchie also serves as a grant reviewer for numerous organizations including the Alzheimer's Association, PA Department of Health and the European Research Council, and is a member of the Genetic Epidemiology Scientific Review COmmittee for the Department of Veterans Affairs.