• How nuclear structure and location within a nucleus affect gene expression
• Chromatin organization and cell differentiation
• The nature of the interactions between the nuclear envelope and the cytoskeleton
• The extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such communication might underlie the disease processes

It is hoped that a better understanding of the mechanisms leading to disease pathogenesis may ultimately lead to more rational and appropriate treatments.