Superbases for Organic Synthesis: Guanidines, Amidines, Phosphazenes and Related Organocatalysts

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Superbases for Organic Synthesis: Guanidines, Amidines, Phosphazenes and Related Organocatalysts

Tsutomu Ishikawa

Description

Guanidines, amidines and phosphazenes have been attracting attention in organic synthesis due to their potential functionality resulting from their extremely strong basicity. They are also promising catalysts because of their potential for easy molecular modification, possible recyclability, and reduced or zero toxicity. Importantly, these molecules can be derived as natural products – valuable as scientists move towards “sustainable chemistry”, where reagents and catalysts are derived from biomaterial sources.

Superbases for Organic Synthesis is an essential guide to these important molecules for preparative organic synthesis. Topics covered include the following aspects:

an introduction to organosuperbases
physicochemical properties of organic superbases
amidines and guanidines in organic synthesis
phosphazene: preparation, reaction and catalytic role
polymer-supported organosuperbases
application of organosuperbases to total synthesis
related organocatalysts: proton sponges and urea derivatives
amidines and guanidines in natural products and medicines

Superbases for Organic Synthesis is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers and those interested in the chemistry of natural products.

About the Author

Professor Tsutomu Ishikawa, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Professor Ishikawa leads a laboratory of researchers at Chiba University in the fields of drug-oriented organic chemistry, natural product chemistry, guanidine-based organic reactions, synthetic studies on aziridines, and the preparation of new polymer-supported reagents. He has published 30 papers, including "Guanidines in Organic Synthesis" - one of the top 5 most downloaded papers of 2006 in the leading organic chemistry journal Synthesis.

To Purchase this product, please visit

https://dev.store.wiley.com/en-ca/Superbases+for+Organic+Synthesis%3A+Guanidines%2C+Amidines%2C+Phosphazenes+and+Related+Organocatalysts-p-9780470740866