• Provides an overview of the hierarchy of study designs, and justifies the position of randomized trials at the top of this hierarchy.
• Discusses the strengths and defects of randomization, and provides real evidence to justify concern regarding its defects.
• Outlays the damaging consequences that selection bias causes when it does occur.
• Considers courses of action that can be taken to manage/contain the problem.
• Presents methods that can be used to detect selection bias in randomized trials, and methods to correct for selection bias.
• Concludes by providing a comprehensive plan for managing baseline imbalances and selection bias in randomized trials, and proposing open problems for future research.

Selection Bias and Covariate Imbalances in Randomized Clinical Trials provides an in-depth overview of a key aspect in the design and analysis of clinical trials, featuring modern and novel approaches to the methodology described. Illustrated with case studies, this book introduces groundbreaking ideas and research that will be invaluable to researchers and practitioners who design and analyse clinical trials. It will also be of interest to graduate students within the field of biostatistics.