Praise for the First Edition:

"All medical statisticians involved in clinical trials should read this book…"
—Controlled Clinical Trials  

Featuring a unique combination ofthe applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. A consolidated review of the field, the Second Edition focuses on computation of randomized tests rather than the asymptotic theory of randomized tests. 

• A discussion on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials
• A new chapter on covariate-adjusted response-adaptive randomization, including minimization techniques and inference for covariate-adaptive randomization
• New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests
• Many problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, to simplify the mathematics, and to ease understanding

Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics.