Pseudo-peptides in Drug Discovery

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Pseudo-peptides in Drug Discovery

Peter E. Nielsen

Description

Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body.
Thus, drug discovery has turned to the novel field of peptidomimetics, i. e. to design non-peptide compounds mimicking the pharmacophore and thus the activity of the original peptide. These novel compounds open up new perspectives in drug design by providing an entire range of highly specific pharmaceuticals that have a high bioavailability.
In particular, the following classes of pseudo-peptides are introduced and examined with regard to their chemical properties, pharmacological activity, as well as practical aspects of synthesis:

* Oligo-glycines
* Beta-peptides
* Gamma-peptides
* Pyrrole-imidazole polyamides
* DNA-like peptide nucleic acids
* Alpha-helical peptide nucleic acids
* DNA-cleaving pseudo-peptides

The first work drawing together knowledge gained on different types of pseudo-peptides with drug properties, this book is an essential resource for drug developers and bioorganic chemists working with those compounds.

About the Author

Peter E. Nielsen has been affiliated with the University of Copenhagen (Denmark) since 1980, and he became full professor at the Department of Medical Biochemistry and Genetics in 1995. He is one of the inventors of peptide nucleic acid (1991), and has further studied and developed this DNA mimic during the last 12 years. In 1998 he co-founded Pantheco A/S (now Santaris A/S), a small biotech company based in Denmark. Peter Nielsen is the co-author of more than 275 scientific papers and 30 patents and patent applications. He received his Ph.B. in 1980 from the University of Copenhagen and an honoroary doctoral degree in 1990. He has also received several scientific awards and is a member of EMBO.

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