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Organic Stereochemistry: Experimental and Computational Methods
ISBN: 978-3-527-33822-1
August 2015
334 pages
Understanding the symmetry of molecules can help to understand and predict a molecule’s properties or the outcome of a stereochemical reaction. In combination with experimental techniques, theoretical tools enable organic chemists to gain a deeper understanding of the mechanism involved as well as obtain information on the stereochemistry of molecules to better understand complex 3D structures.
By combining theoretical knowledge and practical results, this book presents the most popular and useful computational and experimental methods applied for studying the stereochemistry of chemical reactions and compounds, especially natural products.
The book is clearly divided into three parts: Fundamentals, Techniques, and Reactions. The first part provides a brief introduction to the field of chirality and stereochemistry, while the second part covers the different methodologies, such as optical rotation, electronic circular dichroism, vibrational circular dichroism, and Raman optical activity spectroscopy. The third section goes on to describe selective
examples in organic synthesis, classified by reaction type, i.e. enantioselective, chemoselective and stereoselective reactions. A final chapter on total synthesis of natural products rounds off the book.
A valuable reference for researchers in academia and industry working in the field of organic synthesis, computational chemistry, spectroscopy or medicinal chemistry.