Organic Azides: Syntheses and Applications

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Organic Azides: Syntheses and Applications

Stefan Bräse,Klaus Banert

Description

Organic azides are energy-rich and flexible intermediates for organic synthesis. They have found a variety of uses as reagents for the synthesis of heterocycles, as a “masked” amino function in natural compound synthesis, as the most important precursors of nitrenes, and as detonators, blowing agents for polymers, and functional groups in pharmaceuticals. In the past decade completely new perspectives have been developed for the use of azides in peptide chemistry, combinatorial chemistry, and heterocyclic synthesis. Organic azides have assumed an important position at the interfaces between chemistry, biology, medicine, and materials science.

Organic Azides: Syntheses & Applications is an essential guide to the use and applications of this important class of compounds. Topics covered include the following aspects:

synthesis and safety of azides
the chemistry of vinyl azides
small rings by azide chemistry
rearrangement reactions of azides
radical chemistry with azides
cycloaddition reactions with azides
click chemistry with azides
dipolar cycloaddition reactions in peptide chemistry
photochemistry of azides, and the azide/nitrene interface
organometallic chemistry with azides
applications in materials science, including azides in high energy materials, polymers and combinatorial chemistry
applications in bioorganic chemistry, including azides in carbohydrate chemistry, natural products synthesis and Staudinger ligation

Organic Azides: Syntheses & Application is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers, materials scientists and those interested in the chemistry of natural products.

About the Author

Stefan Bräse was born in Kiel, Germany, in 1967 and studied chemistry in Göttingen, Bangor (UK) and Marseille (France). In 1995, he obtained his doctorate after working with Armin de Meijere at the University of Göttingen. After post-doctoral appointments at Uppsala University, Sweden (J.-E. Bäckvall) and The Scripps Research Institute, La Jolla, USA (K. C. Nicolaou), he began his independent research career at the RWTH Aachen associated with Dieter Enders in1997 and finished his habilitation in 2001. He became Professor at the University of Bonn that same year. Since 2003, he is Full Professor at the University of Karlsruhe - in October 2009 renamed to the Karlsruhe Institute of Technology. Stefan Bräse has published more than 100 publications and is recipient of the ORCHEM award in 2000. His research interests include methods in drug-discovery (including drug delivery), combinatorial chemistry towards the synthesis of biologically active compounds, total synthesis of natural products and nanotechnology.

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https://dev.store.wiley.com/en-ca/Organic+Azides%3A+Syntheses+and+Applications-p-9780470519981