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Neurodegenerative Diseases and Metal Ions, Volume 1
ISBN: 978-0-470-01488-2
May 2006
488 pages
Volume 1, offers in 15 stimulating chapters an authoritative view of the fascinating research on Neurodegenerative Diseases and Metal Ions. Written by 41 internationally recognized experts, ithighlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized. With more than 2000 references this book is a vital resource for scientists and advanced students.