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Cancer Diagnostics with DNA Microarrays

ISBN: 978-0-471-78407-4

August 2006

203 pages

Description
Learn how to use DNA microarrays in the fight against cancer

This text provides a first-time comprehensive review and analysis of the state of the art in clinical applications of DNA microarray data in cancer diagnostics. The acclaimed author, an international authority in the field, reviews published clinical trials for ten common cancer types. Moreover, the text provides a meta-analysis of these trials to highlight where the results concur.

The author begins with a discussion of the state of DNA microarray technology, emphasizing important aspects of data analysis. Emerging technologies within the field of DNA microarrays are presented. Next, readers learn the statistical analysis techniques needed to interpret the data. Finally, the author examines some major human cancer types where microarrays have been applied with success. The author concludes, based on the evidence and his own studies in the field, that the results are so convincing for several cancer types that DNA microarrays are ready to be deployed in clinical practice.

The text provides many features for researchers and clinicians who want to use microarrays as a hands-on diagnostic tool, including:

  • Examples and mini-cases that illustrate real-world applications
  • Further reading suggestions in each chapter to facilitate continued investigation of particular topics
  • Detailed recipes and software code for executing the techniques and analysis described in the text
  • Accessible, straightforward presentations that do not presume special training in statistics or bioinformatics

With the promise of DNA microarrays leading to more accurate cancer diagnoses, this text is an invaluable guide that opens the door to better care for cancer patients.

About the Author
STEEN KNUDSEN, PhD, is Director of Research at the Medical Prognosis Institute where he is now taking DNA microarrays into the clinic. Dr. Knudsen is a pioneer in the field of bioinformatics, having published a groundbreaking paper in Nature in 1990. He is also author of the critically acclaimed Guide to the Analysis of DNA Microarray Data (Wiley).
Features
  • First book of its kind to deal with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers 
  • Offers clinicians summary presentation of state-of-the-art science of DNA microarrays, but this can be skipped over to clinical application content
  • Addresses the needs of end users — researchers and physicians -- using microarrays as a tool to be applied in common clinical situations 
  • Accessible without special training in statistics or bioinformatics
  • Huge number of examples and mini-case studies throughout, illustrating both the scientific and research content as well as the clinical application of microarray data and analysis
  • Clinical application content presented with all appropriate specifics of diagnosis and treatment for a broad range of cancers
  • Each chapter includes Bibliographic and Further Reading suggestions