Antiviral Drug Strategies

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Antiviral Drug Strategies

Erik De Clercq,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers

Description

New viruses can arise very quickly and, if unchecked, result in major pandemics. Obvious examples being the AIDS and SARS virus. In order to deal with such imminent threats, drug development times need to be cut short. This is only possible by relying on proven strategies and adapting them to the specific features of any new virus or virus variant.
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It is edited by Erik de Clercq, a world authority on antiviral drug discovery.
The volume covers a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases, and primases, as well as their known inhibitors. The book also contains several case studies of recent successful antiviral drug development.
As a result, medicinal and pharmaceutical chemists, as well as virologists will be able to pinpoint strategies for combating future viral pandemics.

About the Author

Erik De Clercq, M.D., PhD is currently President of the Rega Foundation, a member of the Belgian (Flemish) Royal Academy of Medicine and of the Academia Europaea, and a Fellow of the American Association for the Advancement of Science. He is an active Emeritus Professor of the Katholieke Universiteit Leuven (K.U.Leuven), Belgium. He is honorary doctor of the Universities of Ghent, Belgium, Athens, Greece, Ferrara, Italy, Jinan (Shandong), China, Charles (Prague), Czech Republic, and Jihoceska (Ceske Budejovice), Czech Republic, and Tours, France.
For his pioneering efforts in antiviral research, Professor De Clercq received in 1996 the Aventis award from the American Society for Microbiology, and in 2000 the Maisin Prize for Biomedical Sciences from the Belgian National Science Foundation. In 2008 he was elected Inventor of the Year by the European Union. Jointly with Dr. Anthony Fauci, Prof. De Clercq received the Dr. Paul Janssen Award for Biomedical Research in 2010.
He is the (co)inventor of a number of antiviral drugs, used for the treatment of HSV (valaciclovir, Valtrex , Zelitrex ), VZV (brivudin, Zostex , Brivirac , Zerpex ), CMV (cidofovir, Vistide ), HBV (adefovir dipivoxil, Hepsera ), and HIV infections (AIDS) (tenofovir disoproxil fumarate, Viread ).

Series

Methods & Principles in Medicinal Chemistry

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