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Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation

ISBN: 978-0-470-34341-8

March 2010

736 pages

Description
This text offers the first systematic compilation of various techniques and methodologies used in the analysis of intrinsically disordered proteins (IDPs). Its coverage addresses one of the hottest yet least documented areas in protein biophysics today, summarizing recent achievements in the methods for structural characterization of intrinsically disordered proteins. The text also addresses structural biology and protein degradation, along with a myriad of spectroscopic techniques that can be used to elucidate protein structure: NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis.
About the Author
Vladimir N. Uversky, PhD, is a Senior Research Professor at the Indiana University School of Medicine. He obtained his academic degrees from Moscow Institute of Physics and Technology (PhD) and the Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences. Professor Uversky has authored over 300 scientific publications and edited several books and book series on protein structure, function, folding, and misfolding. He is also an editor of several scientific journals.

Sonia Longhi, PhD, is a Director of Research at the Center for the National Scientific Research (CNRS), heading the Structural Disorder and Molecular Recognition group within the AFMB laboratory. She obtained her PhD from the Università degli Studi of Milan in 1993. She has authored more than sixty scientific publications and edited a book on measles virus nucleoprotein.