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Drug-Induced Long QT Syndrome

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ISBN: 978-0-879-93468-2

September 2002

Wiley-Blackwell

120 pages

Description

To most cardiologists, the long QT syndrome is a relatively rare congenital and familial syndrome that affects children or young adults. However, in addition to congenital LQTS there is a series of acquired forms of the syndrome, usually resulting from exposure to drugs that extend the duration the QT interval. This prolongation may be the primary pharmacodynamic action of the drug, however a plethora of other drugs, including some types of antibiotic, antipsychotics, antidepressants, antimalarials and antihistamines may provoke QT interval prolongation.

The aim of the Clinical Approaches to Tachyarryhthmias series is to update the physician, cardiologist, and all those responsible for the the care of patients with cardiac arrhythmias. In this volume, Dr. Yap and Dr. Camm expose the data implicating a large number of drugs as potential QT prolongators.

About the Author

Yee Guan Yap, Malaysian cardiologist, researcher. Achievements include identification of patients at high risk of sudden death after myocardial infarction and interventional cardiology. Research fellowship British Heart Foundation, 1997-1998, grantee, 1998, 2000; recipient Vale of Trent Audit prize faculty of Royal College General Practitioners, 1992. Yap, Yee Guan was born on December 19, 1967 in Mentakab, Pahang, Malaysia. Arrived in England, 1985. Bachelor in Medical Science with honors, University Nottingham, 1990. Bachelor of Medicine, Bachelor of Surgery, University Nottingham, 1992. Doctor of Medicine, University London, 2005. Achievements include identification of patients at high risk of sudden death after myocardial infarction and interventional cardiology. Fellow Academy Medicine Singapore, Royal College Physicians Glasgow, Royal College Physicians Edinburgh, European Society Cardiology, Society Cardiovasc. Angiography and Interventions, American Heart Association.

Features
This essential monograph:

  • exposes the data implicating a large number of drugs as potential QT prologators

  • highlights the danger of drug-induced proarrhythmia

  • indicates the risks and precautions necessary to minimize proarrhythmia