Over the years, metabolite identification and characterization have progressed to the point where they now play a major role in drug discovery and development. In particular, the metabolite elucidation of xenobiotics has been instrumental in increasing the success rate of selected drug candidates that hold the most promise for being safe and effective.

To explore the analytical possibilities present in this field, this book provides in-depth coverage on designing, developing, and advancing metabolite characterization for drug research. It discusses topics ranging from how and when to perform metabolite identification and characterization to perspectives on regulatory requirements. Biotransformation and Metabolite Elucidation of Xenobiotics also:

• Excellent primer and updated chapter on human biotransformation by Dr. Parkinson

• Supplies up-to-date details on the tools and techniques needed to perform metabolite identification

• Presents modern approaches and strategies to deal with metabolite characterization, using techniques such as LC-MS , H-D exchange, stable isotopes, and LC-MS-NMR

• Provides case studies to help improve the decision-making process in the structural modification of drug candidates?enhancing metabolic stability, improving PK properties, and reducing toxicity

• Includes FDA guidelines such as "Safety Testing of Drug Metabolites"

Giving direction and focus to improving drug discovery techniques, Biotransformation and Metabolite Elucidation of Xenobiotics is a pioneering guide rich in content that displays the verve of experts passionate about their work. It carefully and systemically approaches educating researchers and students to instill them with a better understanding on how to apply the principles of metabolite identification to create drugs that are safer, more targeted, and able to perform to the highest standards.